Logo do repositório

Percorrer por autor "Nascimento, H."

A mostrar 1 - 3 de 3
  • Doença da Inclusão das Microvilosidades: A importância do trabalho de enfermagem na doença crónica grave
    Publication . Oliveira, A.; Nascimento, H.; Monteiro, J.; Mendonça, J.
    A doença da inclusão das microvilosidades é um distúrbio congénito das células epiteliais do intestino, que se manifesta essencialmente por diarreia aquosa persistente desde o primeiro dia de vida. É um distúrbio raro, de etiologia desconhecida, de provável transmissão autossómica recessiva (AR). Não existe terapêutica curativa, o que torna estas crianças totalmente dependentes de nutrição parentérica total. Com o transplante de intestino delgado, quando bem sucedido nasce uma nova esperança para a resolução desta patologia. O papel do enfermeiro é essencial no apoio psicológico aos pais, nos ensinos relativamente ao manuseamento do cateter venoso central e na administração da nutrição parentérica total. ABSTRACT The microvillus inclusion disease is a congenital disorder of the intestine epithelial cells that present essentially by persistent watery diarrhea since the first day of life. It is a rare disorder of unknown etiology probably transmitted as an autossomal recessive trait. No curative therapy exists and children with this disease become totally dependent of parenteral nutrition. With the small bowel transplantation, when well succeeded, a new hope is born for the resolution of this pathology. The nurse’s role is essential on the psychological support of the parents, as well as teaching how to manoeuvre the central venous catheter and the administration of the parenteral nutrition.
    2007-06Artigo científico Acesso aberto Ver mais
  • 2012-06-29Documento de conferência Acesso aberto Ver mais
  • Potential cardiovascular risk protection of bilirubin in end-stage renal disease patients under hemodialysis
    Publication . Sameiro-Faria, M.; Kohlova, M.; Ribeiro, S.; Rocha-Pereira, P.; Teixeira, L.; Nascimento, H.; Reis, F.; Miranda, V.; Bronze-da-Rocha, E.; Quintanilha, A.; Belo, L.; Costa, E.; Santos-Silva, A.
    We evaluated the potential cardiovascular risk protection of bilirubin in hemodialysis (HD) patients. An enlarged set of studies were evaluated in 191 HD patients, including hematological study, lipid profile, iron metabolism, nutritional, inflammatory markers, and dialysis adequacy. The TA duplication screening in the UDP-glucuronosyltransferase 1 A1 (UGT1A1) promoter region was also performed. The UGT1A1 genotype frequencies in HD patients were 49.2%, 42.4%, and 8.4% for 6/6, 6/7, and 7/7 genotypes, respectively. Although no difference was found in UGT1A1 genotype distribution between the three tertiles of bilirubin, significant differences were found with increasing bilirubin levels, namely, a decrease in platelet, leukocyte, and lymphocyte counts, transferrin, oxidized low-density lipoprotein (ox-LDL), ox-LDL/low-density lipoprotein cholesterol ratio, apolipoprotein (Apo) A, Apo B, and interleukin-6 serum levels and a significant increased concentration of hemoglobin, hematocrit, erythrocyte count, iron, transferrin saturation, Apo A/Apo B ratio, adiponectin, and paraoxonase 1 serum levels. After adjustment for age these results remained significant. Our data suggest that higher bilirubin levels are associated with beneficial effects in HD patients, by improving lipid profile and reducing the inflammatory grade, which might contribute to increase in iron availability. These results suggest a potential cardiovascular risk protection of bilirubin in HD patients
    2014Artigo científico Acesso aberto Ver mais