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- Monoclonal gammopathy of renal significance: Diagnostic workupPublication . Correia, S.; Santos, S.; Malheiro, J.; Cabrita, A.; Martins, L.; Santos, J.The clinical spectrum of diseases associated with monoclonal gammopathies is wide and they are most commonly the consequence of renal deposition of monoclonal immunoglobulin or its components. The differential diagnosis is difficult and renal biopsy is essential. To distinguish many of these pathologies is necessary to use techniques that are not always available, even in tertiary central hospitals. This review will discuss the clinical presentation, pathologic features, treatment, prognosis and common diagnostic difficulties of these entities.