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Minimally invasive surfactant therapy in preterm infants: towards less invasive management

2021-03Journal article Open access
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dc.contributor.authorMeireles, Daniel
dc.contributor.authorNeiva-Araújo, Luísa
dc.contributor.authorNascimento, Marta
dc.contributor.authorPinho, Liliana
dc.contributor.authorFreitas, Ana Cristina
dc.contributor.authorAlmeida, Alexandra
dc.contributor.authorCarvalho, Carmen
dc.contributor.authorProença, Elisa
dc.date.accessioned2021-09-30T10:28:34Z
dc.date.available2021-09-30T10:28:34Z
dc.date.issued2021-03
dc.description.abstractIntroduction: Minimally invasive surfactant therapy (MIST) is a surfactant administration procedure that intends to reduce intubations and associated risks. The aim of this study was to compare MIST with INtubation-SURfactant-Extubation (INSURE) technique. Material and methods: Retrospective analysis (from January 2015 to June 2019) of preterm infants on nasal continuous positive airway pressure (nCPAP) treated with surfactant. Results: Fifty-four preterm infants were included and divided in two groups: MIST (n=34) and INSURE (n=20). No significant differences were found between groups regarding gestational age (p=0.480), birth weight (p=0.299), fraction of inspired oxygen (FiO2) prior to surfactant (p=0.220), oxygen therapy duration (p=0.306), progression to intubation (p=0.712), or length of Neonatal Intensive Care Unit stay (p=0.778). FiO2 variation before and after surfactant administration was higher in MIST group (14% vs 9%, p=0.078). No significant complications were reported with either technique. Conclusions: MIST is a safe technique in preterm infants on nCPAP. This study shows similar outcomes with MIST and INSURE procedures, with a greater reduction in FiO2 requirements with MIST. Overall, MIST is less invasive and as effective as INSURE in preterm infants.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMeireles D, Neiva-Araújo L, Nascimento M, Pinho L, Freitas AC, Almeida A, Carvalho C, Proença E, Nascer e Crescer - Birth and Growth Medical Journal 2021;30(1): 18-25. doi:10.25753/BirthGrowthMJ.v30.i1.19182pt_PT
dc.identifier.doi10.25753/BirthGrowthMJ.v30.i1.19182pt_PT
dc.identifier.issn2183-9417
dc.identifier.urihttp://hdl.handle.net/10400.16/2499
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherCentro Hospitalar Universitário do Portopt_PT
dc.relation.publisherversionhttps://revistas.rcaap.pt/nascercrescer/article/view/19182pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectINSUREpt_PT
dc.subjectMISTpt_PT
dc.subjectpretermpt_PT
dc.subjectsurfactantpt_PT
dc.subjectventilationpt_PT
dc.titleMinimally invasive surfactant therapy in preterm infants: towards less invasive managementpt_PT
dc.title.alternativeTerapêutica com surfactante em recém-nascidos pré-termo: tendência para uma abordagem menos invasivapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlacePorto, Portugalpt_PT
oaire.citation.endPage25pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage18pt_PT
oaire.citation.titleNascer & Crescer - Birth and Growth Medical Journalpt_PT
oaire.citation.volume30pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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