Publication
Influence of spironolactone on matrix metalloproteinase-2 in acute decompensated heart failure
| dc.contributor.author | Ferreira, J. | |
| dc.contributor.author | Santos, M. | |
| dc.contributor.author | Oliveira, J. | |
| dc.contributor.author | Marques, I. | |
| dc.contributor.author | Bettencourt, P. | |
| dc.contributor.author | Cyrne-Carvalho, H. | |
| dc.date.accessioned | 2016-05-02T11:37:34Z | |
| dc.date.available | 2016-05-02T11:37:34Z | |
| dc.date.issued | 2015-04 | |
| dc.description.abstract | Matrix metalloproteinases (MMPs) are a family of enzymes important for the resorption of extracellular matrices, control of vascular remodeling and repair. Increased activity of MMP2 has been demonstrated in heart failure, and in acutely decompensated heart failure (ADHF) a decrease in circulating MMPs has been demonstrated along with successful treatment. | pt_PT |
| dc.description.abstract | As metaloproteinases de matriz (MMPs) constituem uma família de enzimas importantes para a reabsorção da matriz extracelular e controle do remodelamento e da reparação vasculares. Demonstrou-se aumento da atividade de MMP2 na insuficiência cardíaca, e, na insuficiência cardíaca agudamente descompensada (ICAD), demonstrou-se uma diminuição nas MMPs circulantes juntamente com o tratamento bem-sucedido | pt_PT |
| dc.description.sponsorship | This study was partially funded by Johnson & Johnson | pt_PT |
| dc.identifier.citation | Arq Bras Cardiol. 2015;104(4):308-14 | pt_PT |
| dc.identifier.doi | 10.5935/abc.20140205 | pt_PT |
| dc.identifier.issn | 1678-4170 | |
| dc.identifier.uri | http://hdl.handle.net/10400.16/1936 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Sociedade Brasileira de Cardiologia | pt_PT |
| dc.relation.publisherversion | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2015000400007&lng=en&nrm=iso&tlng=en | pt_PT |
| dc.subject | Heart Failure | pt_PT |
| dc.subject | Spironolactona/therapeutic use | pt_PT |
| dc.subject | Matrix Metalloproteinase 2/ therapeutic use | pt_PT |
| dc.subject | Insuficiência Cardíaca | pt_PT |
| dc.subject | Espironolactona/uso terapêutico | pt_PT |
| dc.subject | Metaloproteinase 2 da Matriz/uso terapêutico | pt_PT |
| dc.title | Influence of spironolactone on matrix metalloproteinase-2 in acute decompensated heart failure | pt_PT |
| dc.title.alternative | Influência da Espironolactona na Metaloproteinase de Matriz 2 na Insuficiência Cadíaca Aguda Descompensada | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Brazil | pt_PT |
| oaire.citation.endPage | 314 | pt_PT |
| oaire.citation.issue | 4 | pt_PT |
| oaire.citation.startPage | 308 | pt_PT |
| oaire.citation.title | Arquivos brasileiros de cardiologia | pt_PT |
| oaire.citation.volume | 104 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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