CD56-Negative Aggressive NK Cell Leukemia Relapsing as Multiple Cranial Nerve Palsies: Case Report and Literature Review

Guerreiro, M.; Príncipe, F.; Teles, M.; Fonseca, S.; Santos, A.; Fonseca, E.; Gomes, P.; Marques, C.; Lima, M.

http://hdl.handle.net/10400.16/2211

Utilize este identificador para referenciar este registo.

Nome:	Descrição:	Tamanho:	Formato:
CD56-Negative Aggressive NK Cell Leukemia.pdf		3.2 MB	Adobe PDF	Ver/Abrir

Contacte-nos

Autores

Resumo(s)

Aggressive natural killer cell leukemia (ANKL) is extremely rare and habitually manifests as a systemic disease with multiorgan failure that rapidly evolves to death. The neoplastic natural killer (NK) cells usually harbor the Epstein-Barr virus (EBV) with a latent viral infection pattern type II; they often have a cytoplasmic CD3ε+ and surface CD3-, CD2+, and CD56+ immunophenotype, and they show complex genetic abnormalities affecting multiple tumor suppressor genes and oncogenes. We present a rare case of CD56-negative ANKL and review the clinical and laboratorial criteria for the diagnosis, as well as the available therapies.

URI

http://hdl.handle.net/10400.16/2211

Citação

Case Reports in Hematology, vol. 2017, Article ID 3724017, 9 pages, 2017. https://doi.org/10.1155/2017/3724017

Editora

Hindawi Publishing Corporation

DOI

10.1155/2017/3724017

Coleções

CM_SHC_Artigos publicados em revistas indexadas na Pubmed/Medline

Métricas Alternativas

Ver registo completo