Sousa, JessicaNisa, Madalena MeiraCoelho, SóniaAntunes, Joaquina2025-11-052025-11-052024-06-30Sousa J, Meira Nisa M, Coelho S, Antunes J. Lymphadenopathy, weight loss, and anal lesion in a teenager. BGMJ [Internet]. 2024 Jun. 27 [cited 2025 Nov. 5];33(2):150-2. Available from: https://revistas.rcaap.pt/bgmj/article/view/273932183-9417http://hdl.handle.net/10400.16/3792Syphilis is a systemic disease with an increasing incidence in adolescents and young adults. Clinical manifestations can be variable and diagnosis requires a high index of suspicion, as syphilis can mimic other systemic diseases. Condylomata lata is a highly infectious manifestation of secondary syphilis, reported in 9-44% of cases. Here is reported the case of an adolescent girl who presented with inguinal lymphadenopathies, urinary and constitutional symptoms, and a history of unprotected sex with her boyfriend, who had been previously diagnosed with a genital ulcer. A complete physical examination was performed, and the detection of an anal lesion raised the hypothesis of perianal condylomata lata as a manifestation of secondary syphilis. All signs and symptoms of infection resolved with treatment. Early detection, appropriate treatment, and prevention of transmission are essential to reduce the burden of the disease.engcondylomata latasecondary syphilissexual educationsexually transmitted infectiontext10.25753/BirthGrowthMJ.v33.i2.27393