Browsing by Author "Marques, L."
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- AVALIAÇÃO DOS SISTEMAS DE VIGILÂNCIA EPIDEMIOLÓGICA CENTRADA NO LABORATÓRIO - ANÁLISE DOS ÚLTIMOS QUATRO ANOSPublication . Aires, E.; Fernandes, A.; Rodrigues, P.; Santos, C.; Calado, E.; Aragão, I.; Marques, L.; Palma, L.; Lopes, L.; Polónia, J.; Oliveira, J.; Vasconcelos, C.AVALIAÇÃO DOS SISTEMAS DE VIGILÂNCIA EPIDEMIOLÓGICA CENTRADA NO LABORATÓRIO - ANÁLISE DOS ÚLTIMOS QUATRO ANOS Ernestina Aires1, Alexandra Fernandes1, Paula Rodrigues1, Cláudia Santos1,2, Elsa Calado1,2, Irene Aragão1, 3, Laura Marques1, 4, Lígia Palma1, 5, Luísa Lopes1, 5, José Polónia1, 6, Júlio Oliveira1, 7, Carlos Vasconcelos1, 8 1Comissão de Controlo da Infecção (CCI), HSA/CHP; 2Serviço de Microbiologia, HSA/CHP; 3Unidade de Cuidados Intensivos Polivalentes (UCIP), HSA/CHP;4Serviço de Pediatria Médica, HMP/CHP; 5Serviço de Neonatologia, MJD/CHP; 6 Serviço de Cirurgia/Unidade 2, HSA/CHP; 7 Serviço de Medicina A, HSA/CHP; 8Serviço de Imunologia Clinica, HSA/CHP Hospital de Santo António, Centro Hospitalar do Porto (HSA/CHP), Porto. Hospital Maria Pia, Centro Hospitalar do Porto (HMP/CHP), Porto. Maternidade Júlio Dinis, Centro Hospitalar do Porto (MJD/CHP), Porto. Introdução A vigilância epidemiológica é a monitorização de todos os aspectos da ocorrência e da propagação da doença que são pertinentes para o seu controlo efectivo. Implica colheita contínua, análise e interpretação dos dados, bem como a divulgação dos mesmos. Os objectivos da VE passam pelo reconhecimento atempado de surtos infecciosos, identificação de doentes infectados/colonizados, implementação de medidas de controlo de infecção adequadas a cada situação, avaliação da eficiência das medidas preventivas e produção de relatórios de acção pela comissão de controlo de infecção. Objectivos O objectivo deste estudo é analisar a incidência de infecção no Hospital Geral de Santo António (HSA), baseado num programa de VE com a finalidade de conhecer a incidência da infecção e promover a utilização dos dados locais na implementação de medidas de controlo de infecção. Material e Métodos Análise dos dados fornecidos pelo laboratório de microbiologia, através da aplicação informática “Vigi@ct”, que disponibiliza à Comissão de Controlo de Infecção os resultados microbiológicos dos produtos biológicos colhidos aos doentes internados no HSA, no período de 2007 a 2010. Resultados As infecções hospitalares têm decrescido. Verifica-se uma diminuição de 5,9 em 2007 para 4,9 infecções por 1000 dias de internamento em 2010. As Infecções do Trato Urinário são as mais frequentes, seguindo-se as Respiratórias. As Infecções da Corrente Sanguínea ocupam o terceiro lugar da tabela e a Infecção do Local Cirúrgico a quarta posição. Os serviços clínicos são envolvidos para discussão dos casos e decisão das medidas de controlo aplicáveis. É uma articulação dinâmica entre os profissionais dos serviços e a CCI, que permite obter resultados positivos no combate à Infecção Nosocomial, e consequente diminuição da incidência das Infecções Associadas aos Cuidados de Saúde. Discussão e Conclusões Os factores que influenciam o desenvolvimento de infecção nosocomial são geralmente a patogenicidade do microrganismo, os factores ambientais, a susceptibilidade do doente e a resistência bacteriana. Globalmente verifica-se que os internamentos têm aumentado, mantendo-se a demora média em cerca de 6 dias. O número de infecções tem reduzido progressivamente. Os microrganismos mais frequentemente identificados foram a Escherichia coli (988 isolados) e a Pseudomonas aeruginosa (778 isolados), seguidas do MRSA com 555 casos isolados. A avaliação dos sistemas de vigilância epidemiológica visa promover a melhor utilização dos recursos do sistema de saúde. Proporciona dados úteis relativamente às tendências das infecções e à eficácia das medidas de controlo de infecção recomendadas pela CCI e implementadas pelos profissionais de saúde. Apresentador: Ernestina Aires, Enfermeira, Comissão de Controlo da Infecção, HSA/CHP; Aluna de Mestrado em Infecções Associadas aos Cuidados de Saúde ECS/UCP.
- Caracterização das infeções em doentes com Síndrome de deleção 22q11.2Publication . Oliveira, M.; Teixeira, C.; Vasconcelos, J.; Neves, E.; Álvares, S.; Guedes, M.; Marques, L.RESUMO Introdução: O Síndrome de deleção 22q11.2 (SD22q11.2) tem uma incidência de 1/2000 a 1/7000 nados-vivos. Caracteriza-se por um grau variável de imunodeficiência que predispõe a infeções, nomeadamente sinopulmonares. Material e métodos: Estudo retrospetivo de 12 doentes, todos apresentando a del22q11.2 de novo, incidindo na caracterização imunológica e no tipo e número de infeções documentadas. Resultados: No que respeita aos estudos imunológicos, um doente apresentava linfopenia T grave e linfopenia B com hipogamaglobulinemia associadas a Síndrome de Evans; dois doentes linfopenia T ligeira transitória; seis linfopenia T ligeira/moderada persistente e três estudo imunológico normal. A incidência média de infeções foi 0.5/ano/doente (1.1/ano/doente abaixo dos três anos de idade). As mais documentadas foram otite média aguda, pneumonia e bronquiolite. Discussão: Encontrou-se um número baixo de infeções/ano/doente e estas ocorreram maioritariamente abaixo dos três anos de idade. As infeções sino-pulmonares foram as mais documentadas e a evolução geralmente benigna. O caráter transitório idade-dependente das alterações imunológicas e a normal função dos linfócitos, mais do que o grau de linfopenia T, parecem contribuir para este facto. ABSTRACT Background: The 22q11.2 deletion syndrome (SD22q11.2) has an incidence of 1/2000 to 1/7000 live births. It is characterized by a variable degree of immunodeficiency that predisposes to infections, especially sino-pulmonary. Material and Methods: A retrospective study of 12 patients with del22q11.2 de novo was performed, focusing on the immunological characteristics and the type and number of documented infections. Results: The immunological studies showed one patient had severe T lymphopenia T and B lymphopenia with hypogammaglobulinemia associated with Evans syndrome, two patients had transient mild T lymphopenia, six had mild to moderate persistent T lymphopenia and three presented a normal immunological study. The mean incidence of infections was 0,5/year/patient (1,1/year/patient under age three). The most frequent were acute otitis media, pneumonia and bronchiolitis. Discussion: There was a low number of infections/year/patient, and these occurred mostly under the age of three years. The sino-pulmonary infections were the most documented and the evolution was generally benign. The transient and age-dependent nature of the immunological changes and the normal immune cell function, rather than the degree of T lymphopenia appear to contribute to this fact.
- Défice selectivo de IgA – casuística de 6 anosPublication . Teixeira, C.; Cunha, J.; Lopes, I.; Soares, S.; Marques, L.Introdução: A deficiência selectiva de Imunoglobulina A (IgA) é a imunodeficiência primária mais frequente. Está associada a diversas patologias com diferentes apresentações, nomeadamente patologia infecciosa, alérgica, gastrointestinal, doenças auto-imunes e neoplásicas. Objectivo: Analisar as características clínicas e laboratoriais de crianças com défice de IgA seguidas no Hospital de Crianças Maria Pia. Material e Métodos: Análise retrospectiva de processos de crianças e adolescentes com défice selectivo de IgA, no período compreendido entre 1 de Janeiro de 2000 e 31 de Dezembro de 2005. Foram obtidos dados relativos ao sexo, idade do diagnóstico, patologia associada e parâmetros laboratoriais nomeadamente, doseamento de IgM, IgG e IgE, subclasses de IgG, presença de anticorpos antinucleares (ANAs), factor reumatóide (FR) e anticorpos específicos. Resultados: Foram avaliadas 50 crianças, sendo 56%(28) do sexo masculino. A mediana da idade de diagnóstico foi de 6 anos. As manifestações clínicas associadas foram infecções recorrentes das vias aéreas superiores em 50%(25), asma em 34%(17), rinite alérgica em 22%(11), pneumonia em 18%(9), giardíase em 6%(3), doença celíaca em 8%(4), e doenças auto-imunes em 8%(4). Na avaliação laboratorial, observaram-se níveis de IgG aumentados em 42%(21) dos casos. Discussão e Conclusão: Os resultados apresentados estão de acordo com outras séries publicadas. Este trabalho salienta a grande variabilidade de apresentação clínica do défice de IgA. O seu conhecimento permitirá um diagnóstico precoce e orientação adequada. ABSTRACT Introduction: Selective immunoglobulin A (IgA) deficiency is the most frequent primary immunodeficiency. It is associated with diverse pathologies with different presentations, namely infectious, allergic, gastrointestinal, auto-immune and neoplastic disorders. Objective: Analyse clinical and laboratorial characteristics of children with IgA deficiency attending Maria Pia Children’s Hospital. Matherial and Methods: Retrospective analysis of IgA deficient children and adolescent clinical files, in the period from the1st January 2000 until the 31st December 2005. We collected information on sex, age at diagnosis, associated diseases and laboratory data, namely IgM, IgG and IgE, IgG subclasses, presence of antinuclear antibodies, rheumatoid factor, and specifi c antibodies. Results: Fifty children were evaluated, 56%(28) of them were males. The median of age was 6 years. The associated clinical manifestations were recurrent upper airway infections in 50%(25), asthma in 34%(17), allergic rhinitis in 22%(11), pneumonia in 18%(9), Giardia infection in 6%(3), celiac disease in 8%(4), and autoimmune diseases in 8%(4). On laboratory evaluation, high IgG levels were observed in 42%(21) of cases. Discussion and Conclusion: The results presented are similar to other published series. This work points out that IgA deficiency has a great variability of clinical presentation. This knowledge will allow a rapid diagnosis and an adequate orientation.
- Infecção pelo vírus de imunodeficiência humana na criança - aspectos psicossociaisPublication . Fontes, C.; Marques, L.; Santos, M.C.As autoras têm-se confrontado com os problemas psicossociais apresentados pelas crianças e jovens infectados pelo vírus da imunodeficiência humana (VIH), acompanhados na consulta das Doenças Imunológicas do Hospital de Crianças Maria Pia. Face à natureza e particularidades dos problemas, que abrangem toda a família, decidiram proceder a uma revisão bibliográfica dos problemas psicológicos, psiquiátricos e do neurodesenvolvimento que podem surgir nestas crianças; a questão do segredo e da revelação do diagnóstico à criança e jovem são aspectos valorizados nesta pesquisa. ABSTRACT The authors have faced complex psychosocial issues from children and adolescents infected with the human immunodeficiency virus (HIV) followed at the Immunodeficiency Clinics in Maria Pia Children´s Hospital in Porto – Portugal. The nature and particularities of problems that overwhelm these families have led the authors to proceed to a biblyographic review of the psychological, psychiatric and neurodevelopment aspects of these children. Secrecy and diagnostic disclosure issues are particularly emphasised.
- Long-term trends in mortality and AIDS-defining events after combination ART initiation among children and adolescents with perinatal HIV infection in 17 middle- and high-income countries in Europe and Thailand: A cohort studyPublication . Judd, A.; Chappell, E.; Turkova, A.; Le Coeur, S.; Noguera-Julian, A.; Goetghebuer, T.; Doerholt, K.; Galli, L.; Pajkrt, D.; Marques, L.; Collins, I.; Gibb, D.; González-Tome, M.; Navarro, M.; Warszawski, J.; Königs, C.; Spoulou, V.; Prata, F.; Chiappini, E.; Naver, L.; Giaquinto, C.; Thorne, C.; Marczynska, M.; Okhonskaia, L.; Posfay-Barbe, K.; Ounchanum, P.; Techakunakorn, P.; Kiseleva, G.; Malyuta, R.; Volokha, A.; Ene, L.; Goodall, R.Background: Published estimates of mortality and progression to AIDS as children with HIV approach adulthood are limited. We describe rates and risk factors for death and AIDS-defining events in children and adolescents after initiation of combination antiretroviral therapy (cART) in 17 middle- and high-income countries, including some in Western and Central Europe (W&CE), Eastern Europe (Russia and Ukraine), and Thailand. Methods and findings: Children with perinatal HIV aged <18 years initiating cART were followed until their 21st birthday, transfer to adult care, death, loss to follow-up, or last visit up until 31 December 2013. Rates of death and first AIDS-defining events were calculated. Baseline and time-updated risk factors for early/late (≤/>6 months of cART) death and progression to AIDS were assessed. Of 3,526 children included, 32% were from the United Kingdom or Ireland, 30% from elsewhere in W&CE, 18% from Russia or Ukraine, and 20% from Thailand. At cART initiation, median age was 5.2 (IQR 1.4-9.3) years; 35% of children aged <5 years had a CD4 lymphocyte percentage <15% in 1997-2003, which fell to 15% of children in 2011 onwards (p < 0.001). Similarly, 53% and 18% of children ≥5 years had a CD4 count <200 cells/mm3 in 1997-2003 and in 2011 onwards, respectively (p < 0.001). Median follow-up was 5.6 (2.9-8.7) years. Of 94 deaths and 237 first AIDS-defining events, 43 (46%) and 100 (42%) were within 6 months of initiating cART, respectively. Multivariable predictors of early death were: being in the first year of life; residence in Russia, Ukraine, or Thailand; AIDS at cART start; initiating cART on a nonnucleoside reverse transcriptase inhibitor (NNRTI)-based regimen; severe immune suppression; and low BMI-for-age z-score. Current severe immune suppression, low current BMI-for-age z-score, and current viral load >400 c/mL predicted late death. Predictors of early and late progression to AIDS were similar. Study limitations include incomplete recording of US Centers for Disease Control (CDC) disease stage B events and serious adverse events in some countries; events that were distributed over a long time period, and that we lacked power to analyse trends in patterns and causes of death over time. Conclusions: In our study, 3,526 children and adolescents with perinatal HIV infection initiated antiretroviral therapy (ART) in countries in Europe and Thailand. We observed that over 40% of deaths occurred ≤6 months after cART initiation. Greater early mortality risk in infants, as compared to older children, and in Russia, Ukraine, or Thailand as compared to W&CE, raises concern. Current severe immune suppression, being underweight, and unsuppressed viral load were associated with a higher risk of death at >6 months after initiation of cART.
- Membranoproliferative glomerulonephritis and x-linked agammaglobulinemia: an uncommon associationPublication . Lavrador, V.; Correia, F.; Sampaio, R.; Candido, C.; Sameiro-Faria, M.; Marques, L.; Mota, C.Introduction. X-linked agammaglobulinemia (XLA) is a primary immunodeficiency characterized by agammaglobulinemia requiring replacement treatment with immunoglobulin. The association of XLA and membranoproliferative glomerulonephritis (MPGN) is unexpected and, to our knowledge, only one case was previously published. Case Report. The authors report the case of a 10-year-old boy with family history and prenatal diagnosis of XLA, treated from birth with intravenous immunoglobulin replacement therapy. He presented with pneumonia, macroscopic hematuria, nephrotic proteinuria, hypoalbuminemia, and hypercholesterolemia with normal renal function and serum complement levels. Renal histology showed immune complex mediated MPGN. He was started on high dose prednisolone and ramipril and switched to weekly subcutaneous immunoglobulin. After a 4-month treatment, hematuria and proteinuria significantly improved and prednisolone was gradually tapered without relapse. Conclusion. The pathogenic process underlying MPGN development in this patient is unknown but residual humoral immunity might play an important role. Thus, this case highlights the risk of autoimmune disorders among patients with XLA
- Nephrogenic diabetes insipidus associated with tenofovir administration: report of a paediatric casePublication . Costa, M.; Teixeira, C.; Costa, A.; Faria, M.; Mota, C.; Marques, L.Tenofovirrenal toxicity, particularly when associated with other antiretrovirals, has been reported in the adult HIV-positive population. Reports in HIVpositive children are very rare. The authors report a paediatric case of nephrotoxicity associated with tenofovir and didanosine, emtricitabine and lopinavirritonavir coadministration. A 12-year-old girl with AIDS (clinical stage C) with a multidrug-resistant virus and several treatment failures initiated emtricitabine, tenofovir, didanosine and lopinavir-ritonavir in 2008 with good tolerance. Her viral load became undetectable and CD4 count normal. Two years later she presented generalized weakness, polydipsia and polyuria. On physical examination dehydration was evident. Her vital signs were stable. She had lost 5% of her body weight in the previous week. Urinalysis revealed a urine gravity of 1000, osmolality 150 mOsm/Kg and no proteinuria or glucosuria. Blood analysis showed osmolality 289 mOsm/Kg, normal values of glucose, creatinine, urea, sodium, potassium, chloride and calcium. A water restriction test followed by desmopressin administration confirmed the diagnosis of nephrogenic diabetes insipidus. Tenofovir and didanosine were stopped and abacavir was added. The patient was treated with a thiazide diuretic and salt restriction. There was good clinical evolution and no relapses. This case highlights important possible side effects of tenofovir and emphasises the need for further studies into the renal safety of this agent in paediatric patients.
- Pneumonia adquirida na comunidade numa crianc¸a saudável por AcinetobacterPublication . Moreira-Silva, G.; Morais, L.; Marques, L.; Senra, V.Resumo O género Acinetobacter tem sido implicado numa grande variedade de doenc¸as infecciosas, em particular, nas infecc¸ões associadas aos cuidados de saúde. Actualmente há evidência a enfatizar o papel deste microrganismo nas infecc¸ões adquiridas na comunidade. É relatado o caso de uma crianc¸a previamente saudável, de 28 meses de idade, internada por febre associada a tosse e dor localizada no hemitórax esquerdo e cuja radiografia torácica revelou pneumonia necrotisante do lobo inferior. A investigac¸ão diagnóstica efectuada permitiu o diagnóstico de Pneumonia adquirida na comunidade a Acinetobacter lwoffii. A crianc¸a partilhava frequentemente o seu equipamento respiratório com familiares idosos com doenc¸a pulmonar crónica obstrutiva. Dado não terem sido apurados outros factores de risco, considera-se que a partilha do equipamento poderá ter sido o foco infeccioso. Os autores pretendem alertar para a possibilidade de Pneumonia adquirida na comunidade por Acinetobacter lwoffii, numa crianc¸a previamente saudável, relacionada com o mau uso e limpeza dos nebulizadores. Este caso realc¸a o papel emergente desta bactéria, mesmo no contexto comunitário.Abstract Acinetobacter is involved in a variety of infectious diseases primarily associated with healthcare. Recently there has been increasing evidence of the important role these pathogens play in community acquired infections. We report on the case of a previously healthy child, aged 28 months, admitted for fever, cough and pain on the left side of the chest, which on radiographic examination corresponded to a lower lobe necrotizing pneumonia. After detailed diagnostic work---up, community acquired Acinetobacter lwoffii pneumonia was diagnosed. The child had frequently shared respiratory equipment with elderly relatives with chronic obstructive pulmonary disease. As there were no other apparent risk factors, it could be assumed that the sharing of the equipment was the source of infection
- Sepsis por Clostridium Septicum em Criança com Neutropenia Auto-imunePublication . Castillo, M.; Marques, L.; Mesquita, A.; Morais, L.; Senra, V.RESUMO Os autores apresentam o caso clínico de uma criança de sete anos de idade com neutropenia autoimune severa e crónica, refractária à terapêutica, que deu entrada em choque séptico associado a lesões inflamatórias flictenulares perianais. Foi instituída terapêutica antibiótica de largo espectro com cobertura para anaeróbios associada a Imunoglobulina endovenosa em doses elevadas e Filgastrim. A criança manteve instabilidade hemodinamica nas primeiras 72 horas, com evolução favorável posterior. As lesões perianais evoluíram com mionecrose e formação de escaras necessitando de limpeza cirúrgica repetida, enxerto cutâneo e colostomia de protecção. Nas hemoculturas foi isolado Clostridium Septicum. A evolução subsequente foi favorável. Efectuada reconstituição do trânsito com recuperação da continência anal. Actualmente a criança tem dez anos de idade, mantém valores normais de neutrófilos sob terapêutica com Filgastrim e não voltou a ter intercorrências infecciosas. A infecção por Clostridium Septicum é muito rara na criança e ocorre caracteristicamente associada a neutropenia cíclica ou induzida pela quimioterapia, não tendo sido encontrada descrição no contexto de uma neutropenia autoimune na literatura consultada. A taxa de mortalidade é elevada (80%) e a sobrevivência depende da precocidade do diagnóstico e duma terapêutica médica e cirúrgica adequada. ABSTRACT The authors present the clinical case of a seven years old boy suffering a severe and chronic autoimmune neutropenia, resistant to therapy, who was admitted with a septic shock associated to perianal inflammatory lesions. Broad spectrum antibiotherapy associated to high dose of intravenous Immunoglobulin and Filgastrim ware instituted. The child was hemodinamically unstable for the first 72 hours, with subsequent favourable clinical evolution. The perianal lesions evolved to myonecrosis needing repeated surgical intervention to remove necrotic tissues, skin graft and protection colostomy. Clostridium Septicum was isolated from blood cultures. Subsequent evolution was favourable. The colostomy was closed and anal continence was recovered. For the last three years the child maintained normal neutrophil level under filgastrim therapy and had no further infections. Clostridium Septicum infection is rare in children. Neutropenic patients are at a particular high risk for this infection. The authors did not find reports of Clostridium Septicum infection in association with autoimmune neutropenia in the literature reviewed. It is described in patients with cyclic neutropenia or with chemotherapy-induced neutropenia. The mortality rate is high (80%) and survival depends on early diagnosis and appropriate surgical and medical treatment.
- The epidemiology of adolescents living with perinatally acquired HIV: A cross-region global cohort analysisPublication . Slogrove, A.; Schomaker, M.; Davies, M.; Williams, P.; Balkan, S.; Ben-Farhat, J.; Calles, N.; Chokephaibulkit, K.; Duff, C.; Eboua, T.; Kekitiinwa-Rukyalekere, A.; Maxwell, N.; Pinto, J.; Seage, G.; Teasdale, C.; Wanless, S.; Warszawski, J.; Wools-Kaloustian, K.; Yotebieng, M.; Timmerman, V.; Collins, I.; Goodall, R.; Smith, C.; Patel, K.; Paul, M.; Gibb, D.; Vreeman, R.; Abrams, E.; Hazra, R.; Van Dyke, R.; Bekker, L.; Mofenson, L.; Vicari, M.; Essajee, S.; Penazzato, M.; Anabwani, G.; Q Mohapi, E.; N Kazembe, P.; Hlatshwayo, M.; Lumumba, M.; Goetghebuer, T.; Thorne, C.; Galli, L.; van Rossum, A.; Giaquinto, C.; Marczynska, M.; Marques, L.; Prata, F.; Ene, L.; Okhonskaia, L.; Rojo, P.; Fortuny, C.; Naver, L.; Rudin, C.; Le Coeur, S.; Volokha, A.; Rouzier, V.; Succi, R.; Sohn, A.; Kariminia, A.; Edmonds, A.; Lelo, P.; Ayaya, S.; Ongwen, P.; Jefferys, L.; Phiri, S.; Mubiana-Mbewe, Mw.; Sawry, S.; Renner, L.; Sylla, M.; Abzug, M.; Levin, M.; Oleske, J.; Chernoff, M.; Traite, S.; Purswani, M.; Chadwick, E.; Judd, A.; Leroy, V.Background: Globally, the population of adolescents living with perinatally acquired HIV (APHs) continues to expand. In this study, we pooled data from observational pediatric HIV cohorts and cohort networks, allowing comparisons of adolescents with perinatally acquired HIV in "real-life" settings across multiple regions. We describe the geographic and temporal characteristics and mortality outcomes of APHs across multiple regions, including South America and the Caribbean, North America, Europe, sub-Saharan Africa, and South and Southeast Asia. Methods and findings: Through the Collaborative Initiative for Paediatric HIV Education and Research (CIPHER), individual retrospective longitudinal data from 12 cohort networks were pooled. All children infected with HIV who entered care before age 10 years, were not known to have horizontally acquired HIV, and were followed up beyond age 10 years were included in this analysis conducted from May 2016 to January 2017. Our primary analysis describes patient and treatment characteristics of APHs at key time points, including first HIV-associated clinic visit, antiretroviral therapy (ART) start, age 10 years, and last visit, and compares these characteristics by geographic region, country income group (CIG), and birth period. Our secondary analysis describes mortality, transfer out, and lost to follow-up (LTFU) as outcomes at age 15 years, using competing risk analysis. Among the 38,187 APHs included, 51% were female, 79% were from sub-Saharan Africa and 65% lived in low-income countries. APHs from 51 countries were included (Europe: 14 countries and 3,054 APHs; North America: 1 country and 1,032 APHs; South America and the Caribbean: 4 countries and 903 APHs; South and Southeast Asia: 7 countries and 2,902 APHs; sub-Saharan Africa, 25 countries and 30,296 APHs). Observation started as early as 1982 in Europe and 1996 in sub-Saharan Africa, and continued until at least 2014 in all regions. The median (interquartile range [IQR]) duration of adolescent follow-up was 3.1 (1.5-5.2) years for the total cohort and 6.4 (3.6-8.0) years in Europe, 3.7 (2.0-5.4) years in North America, 2.5 (1.2-4.4) years in South and Southeast Asia, 5.0 (2.7-7.5) years in South America and the Caribbean, and 2.1 (0.9-3.8) years in sub-Saharan Africa. Median (IQR) age at first visit differed substantially by region, ranging from 0.7 (0.3-2.1) years in North America to 7.1 (5.3-8.6) years in sub-Saharan Africa. The median age at ART start varied from 0.9 (0.4-2.6) years in North America to 7.9 (6.0-9.3) years in sub-Saharan Africa. The cumulative incidence estimates (95% confidence interval [CI]) at age 15 years for mortality, transfers out, and LTFU for all APHs were 2.6% (2.4%-2.8%), 15.6% (15.1%-16.0%), and 11.3% (10.9%-11.8%), respectively. Mortality was lowest in Europe (0.8% [0.5%-1.1%]) and highest in South America and the Caribbean (4.4% [3.1%-6.1%]). However, LTFU was lowest in South America and the Caribbean (4.8% [3.4%-6.7%]) and highest in sub-Saharan Africa (13.2% [12.6%-13.7%]). Study limitations include the high LTFU rate in sub-Saharan Africa, which could have affected the comparison of mortality across regions; inclusion of data only for APHs receiving ART from some countries; and unavailability of data from high-burden countries such as Nigeria. Conclusion: To our knowledge, our study represents the largest multiregional epidemiological analysis of APHs. Despite probable under-ascertained mortality, mortality in APHs remains substantially higher in sub-Saharan Africa, South and Southeast Asia, and South America and the Caribbean than in Europe. Collaborations such as CIPHER enable us to monitor current global temporal trends in outcomes over time to inform appropriate policy responses.