CM_SO_Artigos publicados em revistas indexadas na Pubmed/Medline
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- Cervical spondylodiscitis in an infantPublication . OLIVEIRA, T.; BARBOSA, C.; NEVES, E.; GUIMARAES, A.; SEXTO, C.; CRUZ, R.An Esp Pediatr. 2000 Apr;52(4):398-400. [Cervical spondylodiscitis in an infant] [Article in Spanish] Oliveira T, Barbosa C, Neves E, Guimarães A, Sexto C, Cruz R. Servicio de Pediatría, Hospital Maria Pia, Porto, Portugal. Abstract Spondylitis in childhood is rare, presenting a great variety of symptoms that are related to the child s age and to the site of the inflammatory process. We present the case of a nine-month-old infant, who presented to the emergency department with a torticollis of six weeks evolution. The diagnosis of spondylitis (C6-C7) was confirmed by MRI. Intravenous antibiotic therapy was administered. The patient showed complete regression of symptoms and imaging tests were normal. The rarity of this disease in patients in this age group, as well as the site and form of presentation are emphasised as is the importance of diagnosing this disease to prevent permanent neurological injuries or bone deformities. PMID: 11003937 [PubMed - indexed for MEDLINE]
- Reconstruction of the anterior cruciate ligament with quadriceps tendon.Publication . NORONHA, J.C.We found 1 article: Arthroscopy. 2002 Sep;18(7):E37. Reconstruction of the anterior cruciate ligament with quadriceps tendon. Noronha JC. Department of Trauma and Orthopaedic Surgery, Hospital Santo António, Porto, Portugal. noronha@mac.com Abstract The author describes the technique he uses to reconstruct the anterior cruciate ligament (ACL) arthroscopically with autologous bone-quadriceps tendon (BQT) graft. The patellar bone is fixed in a femoral tunnel about 2.5 cm long, in a position that allows the tendinous extremity of the graft to appear on the extra-articular exit of the tibial tunnel. The tibial tunnel is filled, making the integration of the tendon in the bone easier. The tendinous extremity of the graft is pulled by nonabsorbable wires, remaining strictly fixed by a staple or a screw in the anterointernal cortex of the tibia. When used in selected cases and when technical details are respected, this technique yields results similar to those obtained with the bone-patella tendon-bone (BPTB) graft. The functional recovery should be more careful with this technique than when the BPTB is used. Generally, less morbidity is seen with the BQT graft. The author believes that the BQT graft will be used more frequently, especially in ACL reconstruction, for patients whose jobs require kneeling or long periods of knee flexion, or in cases of low patella, patellar chondropathy, or tendinopathy of the patellar tendon. This technique may also be appropriate for revision surgeries. PMID: 12209422 [PubMed - indexed for MEDLINE]
- Subjective outcome of reconstruction of the adult acquired neurological equinovarus foot.Publication . Lemos, R.; Pereira, A.Abstract A retrospective study was done of the subjective outcome of surgical correction of a spastic equinovarus foot deformity in 27 adult patients with acquired spastic hemiplegia. The mean age of the patients was 49 years and the mean follow-up period was 29 months. The patients were submitted to individualized soft-tissue surgery intended to correct their deformities and rebalance the affected joints, and subsequently subjected to a standard rehabilitation protocol. The assessment was based on the clinical records and on a questionnaire sent to the patients about relevant aspects of their gait, lifestyle and untoward effects and complications. The results have shown that patients experience frank improvement in terms of gait, orthostatic posture, self-esteem and quality of life. Transient or permanent adverse effects occurred in 11 of the 27 patients. The changes induced by surgery to reduce the imbalance and deformity of the foot have a considerable impact on independence and quality of life of these patients despite the high rate of complications.
- Identification of novel nucleus pulposus markers: Interspecies variations and implications for cell-based therapiesfor intervertebral disc degenerationPublication . Rodrigues-Pinto, R.; Richardson, S.; Hoyland, J.Mesenchymal stem-cell based therapies have been proposed as novel treatments for intervertebral disc degeneration, a prevalent and disabling condition associated with back pain. The development of these treatment strategies, however, has been hindered by the incomplete understanding of the human nucleus pulposus phenotype and by an inaccurate interpretation and translation of animal to human research. This review summarises recent work characterising the nucleus pulposus phenotype in different animal models and in humans and integrates their findings with the anatomical and physiological differences between these species. Understanding this phenotype is paramount to guarantee that implanted cells restore the native functions of the intervertebral disc.
- Giant cell tumours of the small bones of the hands and feet: long-term results of 30 patients and a systematic literature reviewPublication . Oliveira, V.; van der Heijden, L.; van der Geest, I.; Campanacci, D.; Gibbons, C.; van de Sande, M.; Dijkstra, P.Giant cell tumours (GCTs) of the small bones of the hands and feet are rare. Small case series have been published but there is no consensus about ideal treatment. We performed a systematic review, initially screening 775 titles, and included 12 papers comprising 91 patients with GCT of the small bones of the hands and feet. The rate of recurrence across these publications was found to be 72% (18 of 25) in those treated with isolated curettage, 13% (2 of 15) in those treated with curettage plus adjuvants, 15% (6 of 41) in those treated by resection and 10% (1 of 10) in those treated by amputation. We then retrospectively analysed 30 patients treated for GCT of the small bones of the hands and feet between 1987 and 2010 in five specialised centres. The primary treatment was curettage in six, curettage with adjuvants (phenol or liquid nitrogen with or without polymethylmethacrylate (PMMA)) in 18 and resection in six. We evaluated the rate of complications and recurrence as well as the factors that influenced their functional outcome. At a mean follow-up of 7.9 years (2 to 26) the rate of recurrence was 50% (n = 3) in those patients treated with isolated curettage, 22% (n = 4) in those treated with curettage plus adjuvants and 17% (n = 1) in those treated with resection (p = 0.404). The only complication was pain in one patient, which resolved after surgical removal of remnants of PMMA. We could not identify any individual factors associated with a higher rate of complications or recurrence. The mean post-operative Musculoskeletal Tumor Society scores were slightly higher after intra-lesional treatment including isolated curettage and curettage plus adjuvants (29 (20 to 30)) compared with resection (25 (15 to 30)) (p = 0.091). Repeated curettage with adjuvants eventually resulted in the cure for all patients and is therefore a reasonable treatment for both primary and recurrent GCT of the small bones of the hands and feet.
- A Strange GaitPublication . Nascimento, J.; Almeida, E.
- EGR1 controls divergent cellular responses of distinctive nucleus pulposus cell typesPublication . van den Akker, G.; Surtel, D.; Cremers, A.; Hoes, M.; Caron, M.; Richardson, S.; Rodrigues-Pinto, R.; van Rhijn, L.; Hoyland, J.; Welting, T.; Voncken, J.Background Immediate early genes (IEGs) encode transcription factors which serve as first line response modules to altered conditions and mediate appropriate cell responses. The immediate early response gene EGR1 is involved in physiological adaptation of numerous different cell types. We have previously shown a role for EGR1 in controlling processes supporting chondrogenic differentiation. We recently established a unique set of phenotypically distinct cell lines from the human nucleus pulposus (NP). Extensive characterization showed that these NP cellular subtypes represented progenitor-like cell types and more functionally mature cells. Methods To further understanding of cellular heterogeneity in the NP, we analyzed the response of these cell subtypes to anabolic and catabolic factors. Here, we test the hypothesis that physiological responses of distinct NP cell types are mediated by EGR1 and reflect specification of cell function using an RNA interference-based experimental approach. Results We show that distinct NP cell types rapidly induce EGR1 exposure to either growth factors or inflammatory cytokines. In addition, we show that mRNA profiles induced in response to anabolic or catabolic conditions are cell type specific: the more mature NP cell type produced a strong and more specialized transcriptional response to IL-1β than the NP progenitor cells and aspects of this response were controlled by EGR1. Conclusions Our current findings provide important substantiation of differential functionality among NP cellular subtypes. Additionally, the data shows that early transcriptional programming initiated by EGR1 is essentially restrained by the cells’ epigenome as it was determined during development and differentiation. These studies begin to define functional distinctions among cells of the NP and will ultimately contribute to defining functional phenotypes within the adult intervertebral disc.
- Sacral Fractures and Associated InjuriesPublication . Rodrigues-Pinto, R.; Kurd, M.; Schroeder, G.; Kepler, C.; Krieg, J.; Holstein, J.; Bellabarba, C.; Firoozabadi, R.; Oner, F.; Kandziora, F.; Dvorak, M.; Kleweno, C.; Vialle, L.; Rajasekaran, S.; Schnake, K.; Vaccaro, A.STUDY DESIGN: Literature review. OBJECTIVE: The aim of this review is to describe the injuries associated with sacral fractures and to analyze their impact on patient outcome. METHODS: A comprehensive narrative review of the literature was performed to identify the injuries associated with sacral fractures. RESULTS: Sacral fractures are uncommon injuries that result from high-energy trauma, and that, due to their rarity, are frequently underdiagnosed and mistreated. Only 5% of sacral fractures occur in isolation. Injuries most often associated with sacral fractures include neurologic injuries (present in up to 50% of sacral fractures), pelvic ring disruptions, hip and lumbar spine fractures, active pelvic/ abdominal bleeding and the presence of an open fracture or significant soft tissue injury. Diagnosis of pelvic ring fractures and fractures extending to the lumbar spine are key factors for the appropriate management of sacral fractures. Importantly, associated systemic (cranial, thoracic, and abdominopelvic) or musculoskeletal injuries should be promptly assessed and addressed. These associated injuries often dictate the management and eventual outcome of sacral fractures and, therefore, any treatment algorithm should take them into consideration. CONCLUSIONS: Sacral fractures are complex in nature and often associated with other often-missed injuries. This review summarizes the most relevant associated injuries in sacral fractures and discusses on their appropriate management.
- Rheumatic hand's clinical, functional and imagiological correlations following metacarpophalangeal joint silicone arthroplastyPublication . Figueiredo, S.; Pereira, A.; Silva, M.; Leite, L.; Costa, G.; Silva, C.Objective: Evaluation of rheumatoid hand-associated metacarpophalangeal joint silicone arthroplasty most often relies on functional scores alone. This study aimed to understand the correlation between perceived and observed function, strength, and alignment. Methods: Cross-sectional study including all 11 women (15 hands) submitted to second to fifth metacarpophalangeal joint arthroplasty due to rheumatoid arthritis involvement for a time period of seven years. Measurements relied on the Michigan Hand Outcomes Questionnaire, Lafayette Purdue Pegboard, pinch and grip strength, and analysis of a lateral "OK-sign" X-ray view. Correlation analysis used Spearman's coefficient, assuming statistical significance for p-values < 0.05. Results: Objective function was strongly correlated with all other variables (p < 0.05), while perceived function failed to correlate with articular alignment in both measurements (p = 0.240 and p = 0.354). Strength and alignment were also strongly correlated (p < 0.05). Conclusions: Most measurements strongly correlate with each other, with emphasis on objective dexterity measurement.
- Femoral neck stress fracture in a young female recruit: case reportPublication . Fonte, H.; Rodrigues-Pinto, RicardoIntroduction: Femoral neck stress fractures are uncommon and depending on their location, can be at high risk for non-union and significant morbidity. Their prevalence is higher among runners and military recruits, and women seem to be at higher risk. Methods: A 27-year-old female, who was enrolled in military recruit, reported left side groin pain after a strenuous running exercise. Due to persistent pain an X-Ray was ordered, which revealed no signs of acute lesions. Further imaging studies with CT scan and MRI identified a compression-type femoral neck stress fracture. Results: The patient was submitted to conservative treatment consisting of restricting from full weight-bearing. Six weeks after she initiated partial weight-bearing, becoming asymptomatic at seven months. Follow-up imaging studies revealed union of the fracture. Discussion: This diagnosis should be considered when evaluating military and athlete populations. Early recognition of these injuries is crucial because complication and morbidity rates are high.