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Enzymatic vitreolysis for the treatment of tractional diabetic macular edema

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dc.contributor.authorPessoa, Bernardete
dc.contributor.authorCoelho, João
dc.contributor.authorCoelho, Constança
dc.contributor.authorMonteiro, Sílvia
dc.contributor.authorAbreu, Carolina
dc.contributor.authorFigueira, João
dc.contributor.authorMeireles, Angelina
dc.contributor.authorBeirão, João
dc.date.accessioned2020-08-27T10:09:17Z
dc.date.available2020-08-27T10:09:17Z
dc.date.issued2019
dc.description.abstractBackground: A new approach to address focal vitreomacular adhesion in patients with diabetic macular edema may control and stabilize diabetic macular edema with fewer anti-vascular endothelial growth factor injections. Objectives: The aim of this study was to demonstrate that diabetic macular edema can be improved by inducing the release of a vitreomacular adhesion, with less than 2500 μm, with enzymatic vitreolysis. Methods: From a retrospective analysis of clinical records from patients with diabetic retinopathy, patients with diabetic macular edema and vitreomacular adhesion <2500 μm were selected for a single-arm prospective study. The primary endpoint was to control diabetic macular edema with fewer anti-vascular endothelial growth factor injections after an observed vitreomacular adhesion release. A statistical subanalysis was performed for the following two groups: the group with vitreomacular adhesion release (group 1) and the group without vitreomacular adhesion release (group 2). Results: A total of 23 eyes from 19 patients were included. A reduction of the median number of injections was achieved in group 1 (p = 0.006). Adverse events were mild and transitory. Conclusion: Release of vitreomacular adhesion <2500 μm through enzymatic vitreolysis contributed to the control and stabilization of diabetic macular edema with fewer anti-vascular endothelial growth factor injections, reducing the burden and the risks related to these invasive and frequently chronic treatments.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPessoa B, Coelho J, Coelho C, et al. Enzymatic vitreolysis for the treatment of tractional diabetic macular edema. Ther Adv Ophthalmol. 2019;11:2515841419869511. Published 2019 Aug 22. doi:10.1177/2515841419869511pt_PT
dc.identifier.doi10.1177/2515841419869511pt_PT
dc.identifier.issn2515-8414
dc.identifier.urihttp://hdl.handle.net/10400.16/2448
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSAGE Publicationspt_PT
dc.relation.publisherversionhttps://journals.sagepub.com/doi/10.1177/2515841419869511?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200www.ncbi.nlm.nih.govpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectanti-vascular endothelial growth factor injectionspt_PT
dc.subjectdiabetic macular edemapt_PT
dc.subjectocriplasminpt_PT
dc.subjectvitreolysispt_PT
dc.subjectvitreomacular tractionpt_PT
dc.titleEnzymatic vitreolysis for the treatment of tractional diabetic macular edemapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUnited States of Americapt_PT
oaire.citation.startPage2515841419869511pt_PT
oaire.citation.titleTherapeutic advances in ophthalmologypt_PT
oaire.citation.volume11pt_PT
person.familyNamePessoa
person.familyNameCoelho
person.familyNameCoelho
person.familyNameMeireles
person.familyNameBeirão
person.givenNameBernardete
person.givenNameJoão
person.givenNameConstança
person.givenNameAngelina
person.givenNameJoão Nuno Melo
person.identifier.ciencia-id0E1B-7EB2-B90F
person.identifier.ciencia-id7515-8385-064B
person.identifier.ciencia-id0214-5233-EE9D
person.identifier.orcid0000-0002-5673-1561
person.identifier.orcid0000-0003-2261-5682
person.identifier.orcid0000-0002-5331-2257
person.identifier.orcid0000-0001-9148-2786
person.identifier.orcid0000-0001-8642-7010
person.identifier.scopus-author-id7005608345
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationfa0e3b13-5da3-4f74-a184-22358fc19d38
relation.isAuthorOfPublication9d2244b9-b054-46ab-8d35-d0a369849715
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relation.isAuthorOfPublication.latestForDiscoveryfa0e3b13-5da3-4f74-a184-22358fc19d38

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